Selected Publications (scroll down for the full list)
Research Articles
PDF [on avian epiblast] Mak et al, eLife doi: 10.7554/eLife.07178 (2015) Pubmed
PDF [on chick cleavages] Nagai et al, Development 142(7):1279-1286 [PMID: 25742796] on chic(2015) Pubmed
PDF [on blood induction] Weng and Sheng Stem Cell Reports 2(3):262-270 [PMID: 24672750] (2014) Pubmed
PDF [on gastrulation EMT] Nakaya et al, Journal of Cell Biology 202(4):637-651 [PMID: 23940118] (2013) Pubmed
PDF [on streak evo-devo] Alev et al, Development 140(13):2691-6 [PMID: 23698348] (2013) Pubmed
PDF [on streak transcriptome] Alev et al, Development 137(17):2863-2874 [PMID: 20667916] (2010) Pubmed
PDF [on blood development] Shin et al, Development 136(4):595-603 [PMID: 19168675] (2009) Pubmed
PDF [on gastrulation EMT] Nakaya et al, Nature Cell Biology 10:765-775 [PMID: 18552836] (2008) Pubmed
PDF [on blood development] Nakazawa et al, Blood 108(10):3335-43 [PMID: 16888091] (2006) Pubmed
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Review Articles
PDF [on mesenchymal stem cell] Sheng BMC Developmental Biology 15(1):44 PMID: 26589542] (2015) Pubmed
PDF [on epiblast evolution] Sheng Developmental Biology 401(1):17-24 PMID: 25446532] (2015) Pubmed
PDF [on avian development] Sheng Developmental Dynamics 243(3):357-67 [PMID:24550174] (2014) Pubmed
PDF [on EMT and cancer] Nakaya and Sheng Cancer Letters 341(1):9-15 [PMID: 23462225] (2013) Pubmed
PDF [on streak evolution] Bertocchini et al, DGD 55(1):52-9 [PMID: 23157408] (2013) Pubmed
PDF [on blood development] Sheng IJDB 54(6/7):1033-1043 [PMID: 20563984] (2010) Pubmed
PDF [on gastrulation EMT] Nakaya and Sheng DGD 50:755-66 [PMID: 19046163] (2008) Pubmed
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Cover Articles
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Full list of publications (* corresponding author) Pubmed link
S.S. Mak, A. Wrabel, H. Nagai, Y. Matsuoka, R.K. Ladher* and G. Sheng* Zebra finch as a developmental model. Genesis 53:669-677; cover feature [PMID:26385755] (2015) Pubmed
Z. Tan, Z. Hu, E.Y. Cai, C. Alev, T. Yang, Z. Li, J. Sung, Y.Y. El-Sayed, G.M. Shaw, D.K. Stevenson, A.J. Butte, G. Sheng, K.G. Sylvester, H.J. Cohen, X.B. Ling Targeted analysis of an ITIH4 peptide isoform: a serum preterm birth biomarker and population SNP implications. Journal of Genetics and Genomics 42(9):507-10 (2015) Pubmed
H.J. Choi, H.C. Lee, K.S. Kang, H.G. Lee, H. Nagai, G. Sheng and J.Y. Han* Production of interspecific germline chimeras via embryo transplantation. Biology of Reproduction 93(2):36 [PMID: 26063873] (2015) Pubmed
H. Nagai, M. Sezaki, K. Kakiguchi, Y. Nakaya, H.C. Lee, R.K. Ladher, T. Sasanami, J.Y. Han, S. Yonemura and G. Sheng* Cellular analysis of cleavage-stage chick embryos reveals hidden conservation in vertebrate development. Development 142(7):1279-1286 [PMID: 25742796] (2015) Pubmed
G. Sheng* Epiblast morphogenesis before gastrulation. Developmental Biology 401(1):17-24 [review] [PMID: 25446532] (2015) Pubmed
W. Weng and G. Sheng* Five transcription factors and FGF pathway inhibition efficiently induce erythroid differentiation in the epiblast. Stem Cell Reports 2(3):262-270 [PMID: 24672750] (2014) Pubmed
H. Nagai, M. Sezaki, F. Bertocchini, K. Fukuda and G. Sheng* HINTW, a W-chromosome HINT gene in chick, is expressed ubiquitously and is a robust female cell marker applicable in intra-specific chimera studies. Genesis 52(5):424-30 [PMID:24599776] (2014) Pubmed
R. R. Forrest*, ..., G. Sheng, ..., P. Carninci* and Y. Hayashizaki* A promoter level mammalian expression atlas. Nature 507(7493):462-70 [PMID:24670764] (2014) Pubmed
G. Sheng* Day-1 chick development. Developmental Dynamics 243(3):357-67 [review] [PMID:24550174] (2014) Pubmed
B.A.S. McIntyre, C. Alev, R. Mechael, J.B. Lee, Y. Wu, J. Stearns, J. McNicol, M. Levadoux-Martin, G. Sheng and M. Bhatia* Expansive generation of functional airway epithelium from human embryonic stem cells. Stem Cells Translational Medicine 3:7-17 [PMID:24300555] (2014) Pubmed
Y. Nakaya and G. Sheng* Cell shape and cell lineage conversion. Journal of Poultry Science [review] [doi:10.2141/jpsa.010088] (2014) Weblink
H. Nagai, M. Sezaki, H. Nakamura and G. Sheng* Extending the limits of avian embryo culture with the modified Cornish pasty and whole-embryo transplantation methods. Methods 66:441-446; cover feature [PMID: 23707610] (2014) Pubmed
H.C. Lee, H.J. Choi, T.S. Park, S.I. Lee, Y.M. Kim, D. Rengaraj, H. Nagai, G. Sheng, J.M. Lim and J.Y. Han* Cleavage events and sperm dynamics in chick intrauterine embryos. PLoS ONE 8(11):e80631 [PMID:24244702] (2013) Pubmed
R.T.H. Lee, H. Nagai, Y. Nakaya, G. Sheng, P.A. Trainor, J.A. Weston and J-P Thiery* Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme. Development 140:4890-4902 [PMID:24198279] (2013) Pubmed
Y. Nakaya, E. Sukowati and G. Sheng* Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to basal cortex. Journal of Cell Biology 202(4):637-651; cover feature [PMID: 23940118] (2013) Pubmed
Q. Wen, L. Liu, T. Yang, C. Alev, S. Wu, D. Stevenson, G. Sheng, A. Butte and X.B. Ling* Peptidomic identification of serum peptides diagnosing preeclampsia. PLoS ONE 8(6):e65571 [PMID: 23840341] (2013) Pubmed
Papanayotou, I. De Almeida, P. Liao, N. M. M. Oliveira, S. Q. Lu, E. Kougioumtzidou, L. Zhu, A. Shaw, G. Sheng, A. Streit, D. Yu, T. W. Soong and C. D. Stern* Calfacilitin is a calcium channel modulator essential for initiation of neural plate development. Nature Communications 4:1837 [PMID: 23673622] (2013) Pubmed
Alev, Y. Wu, Y. Nakaya and G. Sheng* Decoupling of amniote gastrulation and primitive streak formation reveals a morphogenetic unity in vertebrate mesoderm induction. Development 140(13):2691-6 [PMID: 23698348] (2013) Pubmed
Y. Nakaya and G. Sheng* EMT in developmental morphogenesis. Cancer Letters 341(1):9-15 [review] [PMID: 23462225] (2013) Pubmed
B.A.S. McIntyre, V. Ramos-Mejia, S. Rampalli, R. Mechael, J-H. Lee, C. Alev, G. Sheng and M. Bhatia* Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis. Blood 121(9):1543-52 [PMID: 23293081] (2013) Pubmed
Alev, M. Nakano, Y. Wu, H. Horiuchi* and G. Sheng* Manipulating the avian epiblast and epiblast-derived stem cells. Methods in Molecular Biology 1074:151-173 [PMID: 23975812] (2013) Pubmed
Bertocchini*, C. Alev, Y. Nakaya and G. Sheng* A little winning streak: the reptilian-eye view of gastrulation in birds. Development, Growth and Differentiation 55(1):52-9 [review] [PMID: 23157408] (2013) Pubmed
G. Sheng* and A. C. Foley Diversification and conservation of the extraembryonic tissues in mediating nutrient uptake during amniote development. Annals of the New York Academy of Sciences 1271:97-103 [review] [PMID: 23050970] (2012) Pubmed
Y. Tanaka, M. Hayashi, Y. Kubota, H. Nagai, G. Sheng, S. I. Nishikawa and I. M. Samokhvalov* Early ontogenic origin of the hematopoietic stem cell lineage. Proceedings of National Academy of Sciences 109(12): 4515-4520 [PMID: 22392989] (2012) Pubmed
Nakazawa, C. Alev, L. M. Jakt and G. Sheng* Yolk sac endoderm is the major source of serum proteins and lipids, and is involved in the regulation of vascular integrity in early chick development. Developmental Dynamics 240(8):2002-2010 [PMID: 21761483] (2011) Pubmed
S. Pinho, P. R. Simonsson, K. E. Trevers, M. J. Stower, W. T. Sherlock, M. Khan, A. Streit, G. Sheng and C. D. Stern* Distinct steps of neural induction revealed by Asterix, Obelix and TrkC, genes induced by different signals from the organizer. PLoS ONE 6(4):e19157 [PMID: 21559472] (2011) Pubmed
M. Shin, C. Alev, Y. Wu, H. Nagai and G. Sheng* Activin/TGF-beta signaling pathway regulates Nanog expression in the epiblast during gastrulation. Mechanisms of Development 128(5-6):268-278; cover feature [PMID: 21402155] (2011) Pubmed
Gibson, N. Robinson, A. Streit, G. Sheng and C. D. Stern* Regulation of programmed cell death during neural induction in the chick embryo. International Journal of Developmental Biology 55(1):33-43 [PMID: 21305469] (2011) Pubmed
Nagai, S. Mak, W. Weng, Y. Nagaya, R. Ladher and G. Sheng* Embryonic development of the emu, Dromaius novaehollandiae. Developmental Dynamics 240(1):162-175; cover feature in 240(6) issue [PMID: 21181941] (2011) Pubmed
Nagai, M.C. Lin and G. Sheng* A modified cornish pasty method for ex ovo culture of the chick embryo. Genesis 49(1):46-52; cover feature [PMID: 21086435] (2011) Pubmed
W. Kimura, C. Alev, G. Sheng, L.M. Jakt, S. Yasugi and K. Fukuda* Identification of region-specific genes in the early chicken endoderm. Gene Expression Patterns 11:171-180 [PMID: 21081180] (2011) Pubmed
Y. Nakaya, E.W. Sukowati, C. Alev, F. Nakazawa and G. Sheng* Involvement of dystroglycan in epithelial-mesenchymal transition during chick gastrulation. Cells Tissues Organs 193(1-2):64-73 [PMID: 21051858] (2011) Pubmed
Alev, Y. Wu, T. Kasukawa, L. M. Jakt, H. R. Ueda and G. Sheng* Transcriptomic landscape of the primitive streak. Development 137(17):2863-2874 [PMID: 20667916] (2010) Pubmed
G. Sheng* Primitive and definitive erythropoiesis in the yolk sac: a bird's eye view. International Journal of Developmental Biology 54(6/7):1033-1043; [review; in special issue on developmental hematopoiesis] [PMID: 20563984] (2010) Pubmed
G. Sheng* Vive la difference. Cell Adhesion and Migration 4(3):439; guest editor letter [PMID: 20954294] (2010) Pubmed
Alev, B.A.S. McIntyre, K. Ota and G. Sheng* Dynamic expression of Endoglin, a TGF-beta co-receptor, during pre-circulation vascular development in chick. International Journal of Developmental Biology 54(4):737-742; cover feature [PMID: 2020944] (2010) Pubmed
Alev, K. Shinmyozu, B.A.S. McIntyre and G. Sheng* Genomic organization of zebra finch alpha and beta globin genes and their expression in primitive and definitive blood in comparison with globins in chicken. Development, Genes and Evolution 219(7):353-360; cover feature [PMID: 19609557] (2009) Pubmed
C. Alev, Y. Wu, F. Nakazawa, T. Asahara and G. Sheng* NFATc2 Ser170 phosphorylation marks mitosis in development and ES cells. Cell Cycle 8(11):1803-1805 [PMID: 19395856] (2009) Pubmed
Y. Nakaya and G. Sheng* An amicable separation: chick's way of doing EMT. Cell Adhesion and Migration 3 (2):160-163; primary data/review; cover feature [PMID: 19262172] (2009) Pubmed
M. Shin, H. Nagai and G. Sheng* Notch mediates Wnt and BMP signals in the early separation of smooth muscle progenitors and blood/endothelial common progenitors. Development 136(4):595-603 [PMID: 19168675] (2009) Pubmed
Nakazawa, C. Alev, M. Shin, Y. Nakaya, L.M. Jakt and G. Sheng* PBRL, a putative peripheral benzodiazepine receptor, in primitive erythropoiesis. Gene Expression Patterns 9:114-121 [PMID: 18845277] (2009) Pubmed
Y. Nakaya and G. Sheng* Epithelial to mesenchymal transition during gastrulation: an embryological view. Development, Growth and Differentiation 50:755-766; [review] cover feature [PMID: 19046163] (2008) Pubmed
Nagai and G. Sheng* Definitive erythropoiesis in chicken yolk sac. Developmental Dynamics 237(11):3332-3341 [PMID: 18924232] (2008) Pubmed
Y. Nakaya, E.W. Sukowati, Y. Wu and G. Sheng* RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation. Nature Cell Biology 10:765-775; article; cover feature; News and views feature [PMID: 18552836] (2008) Pubmed
C. Alev, B.A.S. McIntyre, H. Nagai, M. Shin, K. Shinmyozu, L.M. Jakt and G. Sheng* BetaA, the major beta globin in definitive red blood cells, is present from the onset of primitive erythropoiesis in chicken. Developmental Dynamics 237(4):1193-1197 [PMID: 18351667] (2008) Pubmed
B.A.S. McIntyre, C. Alev, H. Tarui, L.M. Jakt and G. Sheng* Expression profiling of circulating non-red blood cells in embryonic blood. BMC Developmental Biology 8(1):21 [PMID: 18302797] (2008) Pubmed
W. Weng, E. Sukowati and G. Sheng* On hemangioblasts in chicken. PLoS ONE 2(11):e1228 [PMID: 18043736] (2007) Pubmed
H. Nagai and G. Sheng* Cis-cotranscription of two beta globin genes during chicken primitive hematopoiesis. PLoS ONE 2(1):e703 [PMID: 17684550] (2007) Pubmed
Ota, H. Nagai and G. Sheng* Expression and hypoxic regulation of hif1alpha and hif2alpha during early blood and endothelial cell differentiation in chick. Gene Expression Patterns 7(7):761-6 [PMID: 17625986] (2007) Pubmed
Nakazawa, H. Nagai, M. Shin and G. Sheng* Negative regulation of primitive hematopoiesis by the FGF signaling pathway. Blood 108(10):3335-43; cover feature [PMID: 16888091] (2006) Pubmed
A.P. Chervenak, P. Basu, M. Shin, L.C. Redmond, G. Sheng and J.A. Lloyd* Identification, characterization and expression pattern of the chicken EKLF gene. Developmental Dynamics 235(7):1933-40 [PMID: 16680725] (2006) Pubmed
Sheng, M. dos Reis and C.D. Stern* Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. Cell 115(5):603-613 [PMID: 14651851] (2003) Pubmed
Sheng and C.D. Stern* Gata2 and Gata3: Novel markers for early embryonic polarity and for non-neural ectoderm in the chick embryo. Mechanisms of Development 87(1-2):213-6 [PMID: 10495290] (1999) Pubmed
G. Sheng, E. Thouvenot, D. Schmucker, D.S. Wilson and C. Desplan* Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. Genes and Development 11(9):1122-31 [PMID: 9159393] (1997) Pubmed
G. Sheng, E. Harris, C. Bertuccioli and C. Desplan* Modular Organization of Pax/Homeodomain Proteins in Transcriptional Regulation. Biological Chemistry 378(8):863-72 [PMID: 9377483] (1997) Pubmed
D. Papatsenko, G. Sheng and C. Desplan* A new rhodopsin in R8 photoreceptors of Drosophila and evidence for coordinate expression with Rh3 in R7 cells. Development 124(9):1665-73 [PMID: 9165115] (1997) Pubmed
C. Bertuccioli, L. Fassano, S. Jun, S. Wang, G. Sheng and C. Desplan* In vivo requirement for the paired domain and the homeodomain of the paired segmentation gene product. Development 122(9):2673-85 [PMID: 8787742] (1996) Pubmed
D.S. Wilson, G. Sheng, S. Jun and C. Desplan* Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proceedings of National Academy of Sciences 93(14):6886-91 [PMID: 8692913] (1996) Pubmed
D.S. Wilson, G. Sheng, T. Lecuit, N. Dostatni and C. Desplan* Cooperative dimerization of paired class homeo domains on DNA. Genes and Development 7(11):2120-34 [PMID: 7901121] (1993) Pubmed